Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Medicine
Sammanfattning: Bleeding diathesis is a common reason for investigation of the haemostatic system and in about 50% of the cases an abnormality is found. Plasminogen activator inhibitor type 1 (PAI-1) is an inhibitor of tissue- and urokinase plasminogen activator (tPA/uPA). High PAI-1 levels are associated with arterial and venous thrombotic conditions but are also seen in pregnancy, inflammatory and infectious diseases, diabetes and overweight. Low levels of PAI-1 have been reported in case studies as a reason for bleeding tendency. Studies of low PAI-1 activity as a cause for bleeding in large populations have so far been lacking. The aim of this thesis was to systematically study the prevalence of low PAI-1 activity in patients with bleeding…
